Product details
Botulinum Toxin Type A is a ~150 kDa zinc-metalloprotease neurotoxin produced by Clostridium botulinum and, by mass, among the most potent biological toxins characterized. Its heavy chain mediates uptake at motor-neuron presynaptic terminals and its light chain cleaves SNAP-25, a SNARE protein required for acetylcholine vesicle docking. It is referenced here strictly as a characterized regulated biological for qualified research contexts — not described for any therapeutic or aesthetic outcome, and not supplied for human administration.
This is the most strongly regulated item in the catalogue. Peptuno makes Botulinum Toxin Type A available only to qualified buyers with explicit import authorization, select-agent / controlled-biological licensing, and chain-of-custody documentation appropriate to their destination jurisdiction; orders require full compliance review — end-user declaration, intended-use specification, and storage / handling confirmation — prior to acceptance, with controlled cold-chain logistics and temperature monitoring on shipment. The material is supplied as the lyophilized 150 kDa complex stabilized with human serum albumin in the standard 100 IU vial format; potency is expressed by bioassay (IU) rather than chromatographic purity alone, since complex integrity governs activity. Sold for Research Use Only.
Regulatory note: Heavily regulated neurotoxin classified as a select agent in the US and under analogous controlled-biological frameworks worldwide. Sold for Research Use Only and only to qualified buyers with appropriate select-agent / controlled-biological licensing, import authorization, and chain-of-custody documentation in their jurisdiction. Order requires full compliance review prior to acceptance; not a finished dosage form and not labelled for human administration.
FAQ
- Why is Botulinum Toxin classified as a select agent, and what does that mean for access?
- It is on the HHS Select Agents and Toxins List in the US (under CDC's Federal Select Agent Program) and analogous controlled-biological lists worldwide, because it is acutely toxic at extremely low doses and carries historical bioweapon concern. In practice a buyer must demonstrate a legitimate research use case, appropriate facility security and storage controls, registered status with the national select-agent regulator, and chain-of-custody documentation throughout the lifecycle. Peptuno verifies all of these before order acceptance.
- How is potency expressed for this biological, and why not chromatographic purity alone?
- Potency is expressed in International Units (IU) by bioassay, because the activity of the toxin depends on the integrity of the ~150 kDa complex rather than on chromatographic purity of a small molecule. A purity figure does not, on its own, capture functional activity for a large protein toxin, so the bioassay IU value is the operative potency statement on the documentation.
- What cold-chain handling does the material require?
- Strict cold-chain throughout: the lyophilized material holds at 2–8 °C with only brief operational excursions, shipped in validated cold-chain packaging with continuous temperature monitoring whose record forms part of the documentation chain. A receiving facility must have validated cold-chain storage in place before delivery; Peptuno's logistics review confirms the receiving facility's cold-chain capability as part of the pre-shipment compliance check.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.