Product details
BPC-157 (Body Protection Compound) is a 15-amino-acid peptide (GEPPPGKPADDAGLV) derived from a protective protein originally isolated from human gastric juice. The sequence is unusually proline-rich, which gives the molecule remarkable resistance to gastric and serum protease degradation, a property that has driven its broad use across tissue-repair research models including tendon-ligament healing, gastrointestinal mucosal protection, vascular endothelial repair, and post-injury bone metabolism studies. BPC-157 has been the subject of regulatory review (most notably the July 2026 FDA Pharmacy Compounding Advisory Committee discussion), but for research buyers the practical considerations are independent of that pathway: chemical purity, sequence verification, and stability of the lyophilised lot.
Peptuno supplies BPC-157 acetate as a lyophilized powder at ≥99.0% HPLC purity. Because BPC-157's relatively short sequence is reliable in solid-phase synthesis but the closely-eluting truncation by-products require careful purification, every batch ships with peak-integration HPLC plus ESI mass spec confirming the molecular weight within 0.5 Da of the theoretical 1419.55 g/mol. Sequence verification by LC-MS/MS (full b- and y-ion ladder) is available on request and is the recommended first-time qualification test for any new BPC-157 supplier, mass alone confirms identity, but tandem MS directly demonstrates the synthesized sequence matches the labelled sequence. BPC-157 is also a standard component of the Wolverine Blend (BPC-157 + TB-500) and the GLOW Blend custom formulations. BPC-157 and TB-500 are mechanistically distinct (proline-rich gastric-protective peptide vs actin-binding 43-mer) but are frequently co-cited in tissue-repair research; the Wolverine Blend SKU provides the canonical 1:1 co-lyophilised pairing.
Regulatory note: Peptuno supplies BPC-157 strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market.
FAQ
- What is the sequence of BPC-157, and why is it so stable?
- BPC-157 is a 15-amino-acid peptide with sequence GEPPPGKPADDAGLV, note the four prolines in the first eight residues (PPPGKP). Proline kinks the peptide backbone in a way that resists protease access, which is why BPC-157 maintains structural integrity in gastric and serum environments where most short peptides degrade quickly. This stability is the molecular basis for the oral-route research interest in BPC-157, distinguishing it from peptides like TB-500 that are usable only via injectable routes.
- Is BPC-157 approved by the FDA, and what's the regulatory trajectory?
- BPC-157 is not an approved finished drug in any major jurisdiction. Peptuno supplies it strictly for Research Use Only; buyers are responsible for verifying ingredient eligibility in their destination market. Regulatory discussions in compounding-pharmacy contexts (e.g. FDA Pharmacy Compounding Advisory Committee proceedings) do not change Peptuno's RUO scope.
- What's the difference between BPC-157 free base and BPC-157 acetate, and which does Peptuno ship?
- BPC-157 acetate is the more commonly produced salt form and is what Peptuno ships by default. Free base BPC-157 is the unsalted molecule and is occasionally requested for formulators who want to control the final counter-ion in their downstream product. The HPLC peak retention time differs slightly between the two forms, acetate elutes earlier under typical reverse-phase conditions, but the biological activity per mass of peptide is equivalent. Specify free base vs. acetate at quote stage if it matters for your downstream work.
- Can BPC-157 be co-formulated with TB-500 in a single vial?
- Yes, the BPC-157 + TB-500 combination is one of the most-requested blends in our catalog, sold as the Wolverine Blend SKU. Co-lyophilization in a single vial is preferred over the buyer mixing the two in solution because it preserves potency better and the analytical packet certifies the actual ratio in the released vial. Standard Wolverine Blend ratios are 5+5 mg in a 10 mg vial; custom ratios (10+5, 10+10, 5+10) are available through Peptuno's custom-synthesis programme. GHK-Cu can also be added to the blend (the GLOW Blend SKU) for combined repair-plus-connective-tissue research.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.