Product details
Erythropoietin (EPO, also called Epoetin) is a 165-amino-acid glycoprotein hormone produced natively by renal interstitial cells and supplied therapeutically as a recombinant glycoprotein biological. EPO is the master regulator of erythropoiesis, signaling through the homodimeric EPO-receptor on erythroid progenitor cells to drive red-blood-cell production. Recombinant EPO (under brand names including Epogen, Procrit, Eprex, NeoRecormon, and many biosimilars) is approved for chemotherapy-induced anemia, anemia of chronic kidney disease, and several other indications globally. The molecule is one of the most stringently controlled biological products in international trade due to both its prescription-medication status and its prominence in athletic-doping enforcement.
Peptuno distributes recombinant EPO only to qualified buyers with appropriate import authorization and dispensing licensing in their destination jurisdiction. As a glycoprotein, EPO's biological activity depends critically on its glycosylation pattern, the same protein backbone with different glycans (Epoetin-alpha vs. Epoetin-beta vs. Darbepoetin-alpha vs. CERA) produces dramatically different in vivo pharmacokinetics. The analytical packet for EPO must therefore include glycan-mapping or isoform-analysis on top of the standard biological-product release testing (SDS-PAGE, peptide-mapping, bioactivity assay, endotoxin, host-cell-protein).
Regulatory note: Highly regulated biological with strict international controls including athletic-doping enforcement. Sold only to qualified buyers with appropriate licensing in their jurisdiction. Order requires full compliance review and import authorization documentation prior to acceptance.
FAQ
- What's the difference between Epoetin-alpha, Epoetin-beta, Darbepoetin, and CERA?
- All four are recombinant EPO products with the same 165-amino-acid protein backbone but different glycosylation patterns and modifications that produce dramatically different pharmacokinetics. Epoetin-alpha (Procrit, Epogen) is the original recombinant EPO, dosed 2-3× weekly. Epoetin-beta (NeoRecormon) has slightly different glycan structure with similar dosing. Darbepoetin-alpha (Aranesp) has hyperglycosylated structure that extends half-life to weekly dosing. CERA (Mircera) is a PEG-conjugated EPO with extended half-life supporting monthly dosing. The protein backbone is identical across all four; the glycan/conjugation differences are what create the pharmacokinetic spectrum. Buyers should confirm which form the released batch represents, they are not interchangeable in clinical or research contexts.
- Why is EPO subject to athletic-doping controls in addition to standard prescription regulation?
- EPO is one of the most heavily monitored compounds in international anti-doping enforcement because exogenous recombinant EPO produces direct erythrocytosis (red-blood-cell increase) that improves oxygen-carrying capacity and endurance performance. Detection methods include direct EPO immunoassay (which distinguishes recombinant from endogenous EPO by isoform pattern) and indirect markers (hematocrit, reticulocyte count, OFF-score). EPO is on WADA's prohibited list at all times for all athletes, and detection windows are several weeks after last dosing. Peptuno's compliance review for EPO orders verifies the buyer's intended use is consistent with clinical or research workflows rather than athletic-performance contexts.
- What documentation is required for EPO import authorization across different jurisdictions?
- EPO import authorisation requirements vary substantially by destination market but generally include: (1) an appropriate research-institution or biological-distribution licence for prescription biologicals, (2) end-user identification (research institution or other qualified buyer), (3) intended-use declaration specifying the research protocol, (4) a chain-of-custody plan covering cold-chain logistics from shipment to administration, and (5) for some markets, pre-approval from the destination's national medicines agency. Specific markets have additional requirements: China's NMPA requires a separate import licence for each batch; EU markets require GDP-compliant distribution licensing; US import requires institutional registration plus state-level licensing where applicable. Peptuno's compliance team supports the documentation requirements during the quote and order workflow.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.