Product details
NAD+ (Nicotinamide Adenine Dinucleotide, oxidized form) is a fundamental coenzyme involved in cellular redox reactions, sirtuin-mediated deacetylation, PARP-mediated DNA damage response, and CD38-mediated calcium signaling. NAD+ levels decline with age across mammalian tissues, and the restoration or boosting of NAD+ is the central thesis of the contemporary longevity-research field, driving extensive interest in NAD+ precursors (NMN, NR) and direct NAD+ supplementation in research contexts. NAD+ is not a peptide but is included in the catalog because of its frequent co-administration alongside peptide research products and its established role in cellular-energy-metabolism workflows.
Peptuno supplies NAD+ at ≥99.0% HPLC purity in lyophilized form. The large fill sizes (100, 500, 1000 mg) reflect the gram-scale dosing typical for biochemical-assay and in vivo research workflows that consume NAD+ stoichiometrically rather than the μg-mg scales of peptide research products. The analytical packet covers RP-HPLC, UV-Vis absorbance at 260 nm (the diagnostic adenine wavelength), and residual-solvent profiling. Storage at -20 °C protected from light extends the lyophilized shelf life; once reconstituted, NAD+ solutions should be used promptly because the molecule is moisture- and oxidation-sensitive in solution.
FAQ
- Is NAD+ a peptide, and how should it be handled differently from peptide products?
- NAD+ is not a peptide, it is a dinucleotide coenzyme consisting of nicotinamide mononucleotide linked to adenosine monophosphate through a pyrophosphate bridge. We include it in the catalog because NAD+ is frequently co-administered alongside peptide research products in longevity-research workflows. The handling differs from peptides in two main ways: (1) the analytical methods are HPLC plus UV-Vis at 260 nm (the adenine absorbance) rather than the peptide-focused HPLC + mass spec + sequence verification, and (2) NAD+ in solution is more sensitive to moisture-driven hydrolysis than lyophilized peptides, so reconstituted solutions should be used promptly rather than stored as working stocks.
- What's the difference between NAD+, NMN, and NR as longevity-research substrates?
- All three feed into the same NAD+ salvage pathway but at different entry points. NMN (Nicotinamide Mononucleotide) is the immediate biosynthetic precursor to NAD+; NR (Nicotinamide Riboside) is converted to NMN and then to NAD+; direct NAD+ supplementation bypasses both precursor steps. The trade-off across the three is dosing convenience versus bioavailability: oral NR has the best oral bioavailability; oral NMN is somewhat poorer but commercially established; direct IV NAD+ has the most rapid systemic effect but requires injection. The choice for research depends on which level of the salvage pathway the experimental question targets.
- Why does NAD+ ship in such large fill sizes (500 mg, 1 g) compared with peptide SKUs?
- NAD+ is consumed stoichiometrically rather than catalytically in many biochemical and cell-culture assays, and the dosing scale is gram-level rather than the μg-mg scale typical of peptide therapeutics. In vivo research protocols can require 250-1000 mg per dose; in vitro NAD+ depletion / rescue experiments routinely use millimolar working concentrations that consume tens to hundreds of mg per replicate. Researchers using NAD+ in cell-culture or biochemical-assay work can use a fraction of the 100 mg fill and store the remainder sealed under nitrogen at -20 °C.
Certificate of Analysis (COA)
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