Product details
0.6% Acetic Acid in Water is an acidic-pH reconstitution diluent for the subset of peptides and recombinant proteins that need acidic conditions for solubilization and monomer stability. The 0.6% acetic-acid concentration gives a reconstituted solution at roughly pH 3.0–3.5 — the working range for proteins such as IGF-1 LR3 and unmodified MGF that aggregate or precipitate at neutral pH but denature under strongly acidic conditions, and for some cationic or amphipathic short peptides with poor neutral-pH solubility. It is supplied as a characterized ancillary diluent rather than a research-target molecule.
Peptuno supplies 0.6% Acetic Acid Water in sterile ampoule format, prepared from pharmaceutical-grade acetic acid and Water for Injection. The release documentation covers the component identities, sterility, and bacterial endotoxin (LAL) per pharmacopeia conventions. Because injectable-grade diluent specifications differ across jurisdictions, buyers should confirm that the sterility, endotoxin, and injectable-grade packaging requirements of their destination market are met before use. Most synthetic peptides reconstitute cleanly in saline or bacteriostatic water — the acidic-pH diluent is the exception for aggregation-prone proteins rather than the default.
Regulatory note: Reconstitution diluent for acidic-pH-requiring peptides; supplied for Research Use Only. Verify sterility, endotoxin (LAL), and injectable-grade packaging compliance with the destination market's pharmacopeia requirements before use.
FAQ
- Which peptides need the 0.6% acetic-acid diluent rather than saline?
- Acidic-pH diluent is for peptides and proteins that aggregate, precipitate, or denature at neutral pH — most commonly IGF-1 LR3 and unmodified MGF, which need acidic conditions for monomer solubilization, and certain cationic / amphipathic short peptides. The majority of synthetic peptides (the GLP-1, repair, and GH-axis reference standards) reconstitute cleanly in saline or bacteriostatic water, so the acidic diluent is the exception; check the peptide's recommended diluent on its COA before defaulting to it.
- Why 0.6% specifically rather than a stronger or weaker acid concentration?
- 0.6% acetic acid gives a final pH around 3.0–3.5 — strong enough to keep aggregation-prone proteins like IGF-1 LR3 in monomer form, but not so strong as to disrupt tertiary structure the way stronger conditions (below pH 2.5) can. Weaker conditions (around pH 4–5) do not protonate enough of the protein's residues to maintain solubility. 0.6% is the established compromise for this class of reconstitution.
- Is this diluent ready for injectable-grade use as supplied?
- It is prepared from pharmaceutical-grade acetic acid and Water for Injection with sterility and endotoxin (LAL) documentation, but injectable-grade specifications differ by jurisdiction. Buyers should confirm the sterility, endotoxin, and packaging requirements of their destination market against the supplied documentation before any injectable-grade research use.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.
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