Product details
Peptuno supplies Semaglutide as a sequence-verified analytical reference standard for GLP-1 pharmacology research. Structurally it is a 31-residue GLP-1 receptor agonist bearing two engineered backbone substitutions plus a C18 fatty-diacid chain anchored at Lys26; that acylation produces the reversible albumin binding and the prolonged circulating profile characteristic of the molecule. As the selective single-receptor GLP-1 agonist, it serves in the metabolic-research literature as the baseline against which the dual- and tri-agonist incretin peptides are benchmarked. It is also the active ingredient of approved finished drugs sold under separate names, but the material here is characterized and labelled strictly as a research reagent.
Every lot is released with its own analytical packet: RP-HPLC purity (gradient method, UV 214 nm), ESI-MS identity within 0.5 Da of the theoretical 4113.58 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide), and water content by Karl Fischer. Since a 31-mer SPPS run yields deletion sequences that co-elute closely on RP-HPLC and cannot be told apart by intact mass, the tandem-MS sequence read is the decisive identity test and is recommended at first-time qualification. Bacterial endotoxin (LAL) is an on-request add-on for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting across a study series; this is reference-grade research material, distinct from compounding-scale API supply.
Regulatory note: Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Semaglutide is the active ingredient of approved finished drugs under separate brand names, but the bulk active supplied here is a research reagent; buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
FAQ
- What are Semaglutide's reference identity values (CAS, formula, MW)?
- Semaglutide CAS is 910463-68-2; molecular formula C187H291N45O59; average molecular weight 4113.58 g/mol. It is a 31-amino-acid GLP-1 receptor agonist with a C18 fatty-diacid albumin-binding moiety on Lys26. Every Peptuno lot confirms identity by ESI-MS within 0.5 Da of the theoretical mass, with the full reference set reproduced on the batch COA so the value can be cited directly in a methods section.
- How does Semaglutide differ from Tirzepatide and Retatrutide in receptor pharmacology?
- Semaglutide is a selective GLP-1 mono-agonist (31 amino acids, C18 fatty-diacid). Tirzepatide is a dual GIP / GLP-1 agonist and Retatrutide a GIP / GLP-1 / glucagon tri-agonist (both 39 amino acids, C20 fatty-diacid). In published metabolic-research readouts the progression from mono- to dual- to tri-agonism corresponds to increasing effects on glucose handling and body composition, which is why the three are studied side by side as a receptor-pharmacology series.
- What documentation ships with Peptuno's Semaglutide for a research workflow?
- Each lot ships with RP-HPLC purity (gradient method, 214 nm), ESI-MS identity within 0.5 Da of 4113.58 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide), and water content by Karl Fischer. Bacterial endotoxin (LAL) is an on-request add-on for in vivo work. The COA reproduces the chromatogram and mass-spec values so the data is citable; raw data files are available as COA attachments for documentation-track buyers.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.
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