Product details
Peptuno supplies Tirzepatide as a sequence-verified analytical reference standard for incretin-pharmacology research. The molecule is a 39-residue synthetic peptide carrying a C20 fatty-diacid substituent on a lysine side chain; that lipidation governs the reversible albumin binding and the long circulating half-life that set it apart from the GLP-1 mono-agonist series. Functionally it behaves as a balanced co-agonist at both the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors, which is why the metabolic-research literature treats it as the reference dual-incretin entity. It is the active ingredient of approved finished drugs marketed under separate names, but the material here is characterized and labelled strictly as a research reagent — not a dosage form.
Each lot is released against its own analytical packet rather than as an undifferentiated bulk fill: RP-HPLC purity (gradient method, UV 214 nm), ESI-MS identity within 0.5 Da of the theoretical 4813.45 g/mol, sequence confirmation by LC-MS/MS, counter-ion content, peptide content (% net peptide), and water content by Karl Fischer. Because the deletion sequences from a 39-mer SPPS run co-elute closely and are not separable by intact mass alone, the tandem-MS b/y-ion ladder is the test that demonstrates sequence identity, and Peptuno recommends requesting it on the first lot from any new source. Bacterial endotoxin (LAL) is an on-request add-on for in vivo metabolic-model work. Fills run mg-scale for reproducible aliquoting across a study series; this is reference-grade research material, distinct from compounding-scale API supply.
Regulatory note: Sold for Research Use Only under the receiving laboratory's institutional and jurisdictional regulations. Not a finished dosage form and not labelled for human administration. Tirzepatide is the active ingredient of approved finished drugs under separate brand names, but the bulk active supplied here is a research reagent; buyers are responsible for institutional biosafety review and verifying import eligibility in the destination market.
FAQ
- What are Tirzepatide's reference identity values (CAS, formula, MW)?
- Tirzepatide CAS is 2023788-19-2; molecular formula C225H348N48O68; average molecular weight 4813.45 g/mol. It is a 39-amino-acid synthetic peptide carrying a C20 fatty-diacid albumin-binding moiety on a lysine side chain. Every Peptuno lot confirms identity by ESI-MS within 0.5 Da of the theoretical mass, with the full reference set (CAS, formula, MW, sequence-verification result) reproduced on the batch COA so the value can be cited directly in a methods section.
- How is Tirzepatide identity confirmed for a metabolic-research workflow?
- Mass spec alone confirms the intact mass but cannot separate a correctly-synthesized 39-mer from closely-related deletion or aspartimide by-products that co-elute on RP-HPLC. Peptuno confirms identity with a combination of RP-HPLC purity (gradient method, 214 nm), ESI-MS within 0.5 Da of 4813.45 g/mol, and sequence verification by LC-MS/MS (b/y-ion ladder). For a lab qualifying a new source, request the tandem-MS sequence data on the first lot; that is the test that demonstrates the supplied sequence matches the labelled sequence rather than only matching the labelled mass.
- How does Tirzepatide differ from Semaglutide in chemistry and receptor pharmacology?
- Both are once-weekly fatty-acid-conjugated incretin-pathway peptides, but the receptor profile differs: Semaglutide is a selective GLP-1 mono-agonist (31 amino acids, C18 fatty-diacid), while Tirzepatide is a balanced GIP / GLP-1 dual agonist (39 amino acids, C20 fatty-diacid). In published metabolic-research readouts the dual-incretin mechanism produces larger effects on glucose handling and body composition than the GLP-1 mono-agonist class at comparable exposures, which is the reason it is a frequent comparator in incretin-pharmacology studies.
- How is Peptuno's Tirzepatide different from a compounding-grade API supply?
- Peptuno supplies Tirzepatide as a reference-grade research reagent, mg-scale, characterized lot-by-lot for reproducible bench and in vivo metabolic research and labelled strictly Research Use Only. That is a different scope from compounding-grade or kg-scale API supply intended for finished-dose preparation. Buyers whose workflow is pharmacy-compounding rather than research should source through a supplier scoped to that use; Peptuno's lots are scoped to the research-documentation chain (HPLC trace, mass spec, sequence verification, stability) that a lab needs to cite in a paper.
Certificate of Analysis (COA)
The per-lot COA for this product will appear here.
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